Oregon coach Dan Lanning challenged his team to see how it would respond to a long road trip on a short week following its 32-31 victory over then-No. 2 Ohio State last week.
The No. 2 Ducks aced that test Friday night.
Jordan James had touchdown runs on Oregon's first two series, Dillon Gabriel threw for two more scores and Oregon delivered its first road shutout since 1992 with a 35-0 rout over Purdue.
"I think we showed what we're capable of," Lanning said. "It's our first shutout in a long time. This conference is tough, and you've got to be able to go on the road and get a win."
Oregon 7-0, 4-0 Big Ten will remain atop the conference standings for another week along with No. 3 Penn State and potentially No. 16 Indiana if the Hoosiers beat Nebraska on Saturday.