Manie Libbok will call the shots on attack for the Springboks against England at Twickenham on Saturday 7.40pm start, while Willie le Roux will have to wait until next year to earn his 100th Test cap.
Springbok coach Rassie Erasmus named a bold match-23 in London on Thursday, which showed 12 changes from the side that beat Scotland 32-15 at Murrayfield last Sunday.
Libbok will be partnered by another attacking force in Grant Williams at halfback, while the back-three of Aphelele Fassi, Cheslin Kolbe and Kurt-Lee Arendse have been reinstated.
As expected, Damian de Allende and Jesse Kriel are reunited at centre, and the regular loose trio of captain Siya Kolisi, Pieter-Steph du Toit and Jasper Wiese are back in harness too.
But Erasmus did make two big calls in his tight five, opting to bring RG Snyman off the bench into the starting side at No 5 lock, and handing in-form Bulls powerhouse Wilco Louw the tighthead prop berth.