Cameron Hanekom is set to make his Test debut off the bench as Hendrikse brothers Jaden and Jordan will be the halfback pairing for the Springboks in Saturdays clash against Wales in Cardiff.
Bulls star Hanekom is likely to make an appearance in the second half at the Principality Stadium for a much anticipated international bow after a series of impressive performances in the United Rugby Championship over the last few years.
It will also be a special occasion for the Hendrikses, who are the 36th set of Bok brothers, when they run out in the No 9 and 10 jerseys on Saturday night.
Bok coach Rassie Erasmus opted to leave out the starting halfbacks from last weeks 29-20 win over England, Grant Williams and Manie Libbok, from the match-23 on Tuesday, with Cobus Reinach and Handr Pollard the reserves in Cardiff.
The other changes are in the pack, with Elrigh Louw coming in for Pieter-Steph du Toit who has a shoulder niggle at blindside flank, while Franco Mostert is reinstated at No 5, with RG Snyman returning to the bench, and Jean Kleyn gets a start at No 4, with Eben Etzebeth a replacement.
