Southgates men begin what they hope will be a road to Berlin for the final on July 14 against Slovakia in Gelsenkirchen on Sunday.
A rematch of the Euro 2020 final with Italy or Switzerland would then await in the quarters, while Austria, Turkey, the Netherlands or Romania are potential semi-final opponents.
There has been little in Englands performances in Germany so far to justify their hype as pre-tournament favourites.
But with Germany, France, Spain and Portugal all on the other side of the draw, the pressure has intensified on a richly-talented squad to finally start performing as a team.
If people are being negative, its only because they expect a lot from you, which is a positive thing, said Newcastle winger Anthony Gordon, who could be one of the changes Southgate turns to.