In recent years, the Springbok versus England rivalry has intensified, particularly after the reigning world champions knocked their opponents out of two consecutive tournaments.
The fallout from last years final - featuring Bongi Mbonambi and Tom Curry - lingers in the air, even though Curry will not be on the field today 7.40 pm start.
analyses five key positional matchups that could shape the games outcome.
Eben Etzebeth vs Maro Itoje
When two of rugby's fiercest enforcers meet, one can expect tensions to flare.