An under-strength Arsenal face a huge test of their Premier League title credentials at rivals Tottenham , while Manchester United boss Erik ten Hag desperately needs a response from his side at Southampton.
AFP Sports looks at the pick of the action as the English top-flight returns from an international break this weekend:
Can Arsenal cope?Arsenal have already blinked first in the title race to fall two points behind Manchester City and Liverpool .
The Gunners were held 1-1 at home by Brighton last time out after Declan Rice was harshly sent-off early in the second half.
Rice is therefore suspended for Sunday's north London derby to compound injury woes for Mikel Arteta .