The 72-year-old had been hospitalised due to an infection in his leg.
The BBC has reported that his daughter informed them he died on Thursday afternoon due to complications from sepsis in the same East London hospital where many of his victims were treated.
In 2021, Van Schoor had both his legs partially amputated following circulatory issues.
Van Schoors death occurred less than a week after a BBC documentary investigation into his past, which revealed horrific new details about a series of killings he committed in the late 1980s in East London while working as a private security guard.
Between 1986 and 1989, he shot and killed at least 39 people. All of his victims were black, with the youngest being just 12-years old. The mass killer, who told the BBC that he hunted black people, said that the police encouraged him.
